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Tire sealants are liquids that are put inside a bike tube which can seal small punctures almost instantly. When a puncture occurs, the compressed air inside the tire forces the sealant through the hole at high velocity. When it contacts the low-pressure air, it coagulates to form a seal. This stuff really works to prevent flats. For holes up to 2mm or so, which is most punctures due to glass, thorns, wire and small tacks, the sealant is very effective.
Slime sealant is optimized for standard butyl tubes. Unfortunately, it can't be inserted through a Presta valve stem because it gums up the valve. To solve this problem, Slime Self-Sealing Tubes are tubes that have Slime sealant pre-installed. It is also possible to insert Slime into your tube by cutting a small hole in the tube, inserting the Slime material, then sealing the hole with a normal tube patch.
Tufo also makes a sealant optimized for use with their tires. It can also be used in other tubular tires. Since the valve core is removable on these tires it is easy to install the sealant and then replace the valve core. Given how hard it is to repair tubular tires, we highly recommend using the sealant. The sealant can be used as a preventative, or for repair after a flat occurs.
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